Saak V. Ovsepian, M.D., Ph.D. in Neurosciences, Electrophysiology and Imaging Expert. S.V. Ovsepian - Official website, Neurosceintist at International Centre for Neutotherapeutics, Dublin City University and Imaging Specialist at the University of Munich, Munich, Germany.



Targeted delivery into motor nerve terminals of inhibitors for SNARE-cleaving proteases via liposomes coupled to an atoxic botulinum neurotoxin. Edupuganti OP, Ovsepian SV, Wang J, Zurawski TH, Schmidt JJ, Smith L, Lawrence GW, Dolly JO. FEBS J. 2012 Jul;279(14) :2555-67. doi: 10.1111/j.1742-4658.2012.08638.x. Epub 2012 Jun 14. [PubMed - PDF]

Intrinsic voltage dynamics govern the diversity of spontaneous firing profiles in basal forebrain noncholinergic neurons. Ovsepian SV, Dolly JO, Zaborszky L. J Neurophysiol. 2012 Jul;108(2):406-18. Epub 2012 Apr 11. [PubMed - PDF]

Extravesicular intraneuronal migration of internalized botulinum neurotoxins without detectable inhibition of distal neurotransmission. Lawrence GW, Ovsepian SV, Wang J, Aoki KR, Dolly JO. Biochem J. 2012 Jan 1;441(1):443-52. [PubMed - PDF]

Enhanced Synaptic Inhibition Disrupts the Efferent Code of Cerebellar Purkinje Neurons in Leaner Ca(v)2.1 Ca (2+) Channel Mutant Mice. Ovsepian SV, Friel DD. Cerebellum. 2012 Sep;11(3):666-80. [PubMed - PDF]


Dendritic SNAREs add a new twist to the old neuron theory. Ovsepian SV, Dolly JO. Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19113-20. Epub 2011 Nov 11. Review. [PubMed - PDF]

Innocuous full-length botulinum neurotoxin targets and promotes the expression of lentiviral vectors in central and autonomic neurons. O'Leary VB, Ovsepian SV, Raghunath A, Huo Q, Lawrence GW, Smith L, Dolly JO. Gene Ther. 2011 Jul;18(7):656-65. doi: 10.1038/gt.2011.8. Epub 2011 Mar 3. [PubMed - PDF]


Enhanced Synaptic Inhibition Slows and Degrades the Efferent Code of Cerebellar Purkinje Neurons in CaV2.1 Channel Mutant Leaner Mice. Ovsepian SV. Neuroscience. 2010 Feb 24. [PubMed - PDF]


Neuro-exocytosis: botulinum toxins as inhibitory probes and versatile therapeutics. Dolly JO, Lawrence GW, Meng J, Wang J, Ovsepian SV. Curr Opin Pharmacol. 2009 Jun;9(3):326-35. Epub 2009 Apr 23. Review. [PubMed - PDF]

Activation of TRPV1 mediates calcitonin gene-related peptide release, which excites trigeminal sensory neurons and is attenuated by a retargeted botulinum toxin with anti-nociceptive potential. Meng J, Ovsepian SV, Wang J, Pickering M, Sasse A, Aoki KR, Lawrence GW, Dolly JO. J. Neurosci. 2009 Apr 15;29(15):4981-92. [PubMed - PDF]


Differential cholinergic modulation of synaptic encoding and gain control mechanisms in rat hippocampus. Ovsepian SV. Neurosci Res. 2008 May;61(1):92-8. Epub 2008 Feb 6. [PubMed - PDF]

The leaner P/Q-type calcium channel mutation renders cerebellar Purkinje neurons hyper-excitable and eliminates Ca2+-Na+ spike bursts. Ovsepian SV, Friel DD. Eur J Neurosci. 2008 Jan;27(1):93-103. Epub 2007 Dec 17. [PubMed - PDF]


Serotonergic modulation of synaptic transmission and action potential firing in frog motoneurons. Ovsepian SV, Vesselkin NP. Brain Res. 2006 Aug 2;1102(1):71-7. Epub 2006 Jun 23. [PubMed - PDF]

Enhancement of the synchronized firing of CA1 pyramidal cells by medial septum preconditioning: time-dependent involvement of muscarinic cholinoceptors and GABAB receptors. Ovsepian SV. Neurosci Lett. 2006 Jan 23;393(1):1-6. Epub 2005 Oct 19. [PubMed - PDF]


Intracellular recording of the frog dorsal root single fibres' responses mediated by the GABAA and 5-HT-receptors. Ovsepian SV, Veselkin NP. Ross Fiziol Zh Im I M Sechenova. 2004 Aug;90(8):1033-40. Russian. . [PubMed - PDF]  

Dual effect of GABA on descending monosynaptic excitatory postsynaptic potential in frog lumbar motoneurons. Ovsepian SV, Vesselkin NP. Neuroscience. 2004;129(3):639-46. . [PubMed - PDF]

Endogenous acetylcholine lowers the threshold for long-term potentiation induction in the CA1 area through muscarinic receptor activation: in vivo study. Ovsepian SV, Anwyl R, Rowan MJ. Eur J Neurosci. 2004 Sep;20(5):1267-75. [PubMed - PDF]


Involvement of GABA(B) receptors in presynaptic inhibition of fibers of the descending projections of the spinal cord in the frog Rana ridibunda. Ovsepian SV, Veselkin NP. Neurosci Behav Physiol. 2003 Nov;33(9):873-81. [PubMed - PDF]


The study of the role of the GABA A and GABA B receptors in presynaptic inhibition of primary afferents of spinal cord of the frog Rana ridibunda. Ovsepian SV, Veselkin NP Zh Evol Biokhim Fiziol. 2002 Nov-Dec;38(6):585-93. Russian. [PubMed - PDF]  

Participation of the GABA B receptors in presynaptic inhibition of the spinal cord descending projections fibers in the frog Rana ridibunda. Ovsepian SV, Veselkin NP. Ross Fiziol Zh Im I M Sechenova. 2002 Jul;88(7):817-28. Russian. [PubMed - PDF


Effects of Serotonin on Primary Afferents in the Frog Spinal Cord. Ovsepian SV, Veselkin NP. Neurophysiology. Volume 33, Number 6, November 2001 , pp. 356-364(9) [PubMed - PDF]